Goal

To develop a new class of medicines that harness the brain-body connection to control physiology, metabolic state, and immunity.

Background and Current Landscape

A new generation of weight loss drugs has demonstrated that it is possible to access the brain’s initial receipt of information through the blood-brain barrier. These advances can be harnessed to enable the body’s homeostatic and inflammatory circuits to detect deviations and engage specialized effector mechanisms to correct them.

Investments in this subdomain explore potential applications of these technologies to elicit healthy physiological set-points and immune responses to starvation, stunting, and infection that can ultimately impact major disease burdens in low-and-middle income countries (LMICs).

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